IGF – 1 LR3

IGF-1 LR3 1mg: Research Overview & Biochemical Profile

Contents

• Product Overview

• Biochemical Characteristics

• Research Applications

• Mechanism of Action

• Storage & Stability

Product Overview

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arginine 3) is a synthetic analog of human insulin-like growth factor-1 (IGF-1) engineered for laboratory research. The “LR3” designation refers to a structural modification: the substitution of glutamic acid with arginine at position 3 and a 13-amino acid N-terminal extension.

These modifications significantly reduce the peptide’s affinity for IGF-binding proteins (IGFBPs), allowing it to remain active in experimental systems up to 120 times longer than standard IGF-1, enhancing its metabolic and proliferative effects in research models.

Biochemical Characteristics

• Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA

• Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉

• Molecular Weight: 9117.5 g/mol

• Purity: 99% (HPLC verified)

• Form: Lyophilized (Freeze-dried) powder

• CAS Number: 946870-92-4

Research Applications

IGF-1 LR3 is a primary tool compound used in laboratory settings to investigate:

1. Cellular Proliferation: Studying the rate of division in muscle, connective, and epithelial tissues.

2. Tissue Remodeling: Investigating the repair and regeneration mechanisms of damaged cells.

3. Metabolic Signaling: Assessing glucose transport and lipid metabolism regulation.

4. Anti-Aging Research: Evaluating the interaction between IGF-1 signaling and cellular senescence.

Mechanism of Action

IGF-1 LR3 functions by activating the IGF-1 Receptor (IGF-1R), which triggers downstream intracellular signaling cascades:

• PI3K-Akt Pathway: Essential for cell survival, growth, and protein synthesis.

• MAPK/ERK Pathway: Regulates gene expression and cell cycle progression.

• Myostatin Inhibition: Preclinical research explores its ability to counteract growth-inhibitory proteins like myostatin to promote muscle fiber development.

Storage & Stability

• Lyophilized State: Stable at room temperature for 3–4 months; however, long-term storage at -18°C is recommended.

• Reconstituted State: Once mixed with bacteriostatic water, it must be refrigerated at 2°C to 8°C. It remains stable for approximately 30 days.

• Shipping: Products are shipped in lyophilized form to ensure maximum stability during transit.